Showing posts with label laboratory standardization. Show all posts
Showing posts with label laboratory standardization. Show all posts

Wednesday, 25 November 2009

Another Perspective on 2008 WADA Laboratory Statistics

When the Honourable John Fahey presided, last November 2008, as Chair of the WADA Executive Committee, his remarks included two important concepts.

First, as to the problem or situation of full Signatory 'compliance', that WADA had “... certainly watered down the black and white approach that many believed should have been taken...”, and secondly, how results achieved via the various Floyd Landis cases proved “... that the system was there and worked properly...”. Our Ww list (of 'Landis Decisions') includes USADA I, USADA/WADA II, AFLD and the settled US Fed. Court case, not to mention the 'Hacking' case still waltzing through the French court system (although Mr Fahey may not have been counting beyond the three US-based cases). Of course, the 'system' to which Mr Fahey refers is the entire WADA system. A question arises, however, as to the consistency of that system's 'efforts'.


In the previous WADAwatch post, legal anomalies for the basis of WADA's statistics reporting for the 2008 Lab Report, were aptly highlighted. That Report included, as an explanation, Footnote 2 (FN2), which justified the inclusion of (within the statistics on legal AAFs) past numbers of “AF (Atypical Finding) results” from 2003 through 2007. Their legal basis to do so (ostensibly to offer well-founded comparative results), remains unclear.


WADAwatch noted three major problems incorporated by this act of Reporting: by including 2008 AF findings in a 2009 official Report, from statistics gleaned from its family of 'accredited laboratories', WADA is 'jumping the gun' by reporting these. AFs were not legally in existence until the ISL, WADC and Tech Docs came into force after January 2009, thus compiling statistics one year early doesn't make sense. Second problem, was that WADA evidently 'knew' (as clear reading of the FN2 reveals) some of its previously-proclaimed AAF Sample analyses (and of course, Athletes) were not AAFs, but had been publicly disclosed as such for those first five years (2003 – 2007), while (now) apparently only being 'AFs', which are lower -threshold anomalies: a 'non-positive', a 'report' provoked by 'atypicality of findings' of a Substance, from whichever body fluid(s) were examined, and for which the Lab's Senior Management wishes to find more information or investigate further. Yet inclusion of the AF stats calls into question how this WADA system appears to be working. The third problem is either moral or legal; if WADA is denominating previously reported AAFs as AFs, up to six years after those AAF were announced, it may have a legal obligation to at least publish the numbers, or identify individual cases that were the basis for these abracadabrasque, statistical sleights-of-hand, now in the end of 2009.


As long as WADA has been operating under its Code, it has promoted the concept of 'laboratory standardization'. To assist in analysing (for our own understanding) the statistics provided by WADA, we developed our own Table of WADA lab statistics, which ranks from 1 to 34 the WADA laboratories by their percentage of achieved 'Findings'. We hesitate to rail against the fact that labs under a 'unified' system, are offering percentages that range from nearly five percent, to barely one-half percent. Take a look at WADAwatch's table, first...


(Save a copy! You have permission; it shows better enlarged.)


The underlying issue resulting from this disclosure of WADA laboratories and their annual reporting of 'Findings', remains pre-eminent: what statistic confirms that WADA has produced a 'standardized system'?


It comes as no surprise which laboratory takes First Place, the systemic Gold Star, by holding the highest percentage of AAF (plus AF) findings. The AFLD 'département des analyses', formerly the French LNDD, holds this 'chapeau'. Following closely are Madrid, Ghent and Prague; these four laboratories complete the group that have 'Findings' results higher than four percent (4pc). Five other labs fill the ranks of labs showing between three and four percent. Nine labs share eight places in labs producing 'Findings' within two to three percent: Lausanne and the newest ('Welcome!') WADA lab from New Delhi, show an identical 'Findings' result (2.46pc). En suite, eleven labs float between one and two percent levels; the lowest group itself, between 0.50 and one percent, includes five labs. See our Table's lower left corner to capture the 'Regional Subtotals', and the lower right shows subtotals by 'percentile'. The 'Top Four' labs, are eleven (11pc) percent of the family of labs (4/34ths) yet created 707 AAFs, a number which equals 23pc of the total 2008 AAFs.


More astonishing analysis comes, however, from examining the number of 'Samples' that were run, by percentile of 'Findings'. The four 'most positive' labs ran just over nine percent of the Samples: 26,115 in sum. The five 'least positive' labs ran 39.84pc of the 2008 Samples: 109,406. The labs that report less than two (2pc) positives but more than one percent, ran 74,723 Samples. That equates to 184,129 Samples, or barely over 67pc of the annual number, showing less than two percent positive 'Findings'.


All four of the 'most positive-findings' laboratories are in Europe; none of the 'least positive-findings' are in Europe: two are from the USA (L.A. and Salt Lake City), two from Asia (Tokyo, Beijing) and Ankara (Turkey: we define 'Europe' as does Nicolas Sarkozy). Our presumption is that WADA is currently questioning these disparate statistics at great length, internally and with correspondence with its Signatories, for the stats call into question 'by what sense' the WADA system is functioning, under the title of 'Laboratory Standardization'. As to the 'champion of positives', under the guidance of AFLD and Pierre Bordry, one might think WADA would add this 'achievement' by that Agency to its analysis, pertaining to various counter-charges levied against the AFLD by the UCI response-report of late October.


The phrase 'the Beauty of Science' has a regular place in texts posted by WADAwatch. When the Beauty of Science is surrounded (Suborned? Submerged?) by national politics, international politics, and the World of Sport, it becomes hard to imagine whether a majority of labs' Sample analyses, which show 'low positives', are 'falsely reporting negatives' that should, de facto be 'positives', or whether the opposite is true.


Standardization of laboratories does not mean, ipso facto, that all must have the same IRMS machine; it should mean that whichever IRMS machine, in all WADA labs, when given a Sample (for control/test purposes) in pristine condition, containing an identical concentration of, let's say Testosterone metabolites such as 5-alpha diol and 5-beta diol, ought to be able to identify those metabolites, and their concentrations, at the anticipated level (within scientifically-accepted, statistically acceptable norms: like 0.001 to 0.0001pc).


It does not mean that all labs should operate (within the variations of linguistic or legal necessity) with the identical Laboratory Chain of Custody (LCOC) form (wouldn't that be nice, though?); it does mean, however, that any legal evidence derived be acceptably sufficient, satisfying WADA (or higher) standards for disciplinary hearings. These are necessities, if the system is not to be perceived as a hodge-podge of 'don't touch my Science!' participants.


Is the Los Angeles laboratory, which ran over seven times as many Samples in 2008 (72,394 to 10,194) and found 'AAF Findings', at a rate over seven times less frequently, (0.64pc to 4.98pc) as did the AFLD lab, a much 'better lab'? Could it be 'full of deceit', and 'aiding Athletes to cheat'? Not likely, is this author's opinion.


Is a perfect laboratory at some median level in between these two 'extremes'? Are they 'Standardized'? WADAwatch certainly cannot answer the dilemma this question provokes.


It can only pose the questions... and salute the true fact: cheating Athletes (rather 'doping Athletes': cheaters still exist, for 'handballs' that allow a trip to the World Cup, or 'betting scandals' that are ricocheting across European football (soccer) leagues) are, evidently, barely one percent of the total (okay: Athletes who are elite enough to reside 'within the international anti-doping system', and using Substances (or Methods) detectable under today's testing/analysis environment) at 1.08pc (1.84pc by adding in the 'premature' AF numbers). That's a far cry from the 'mob mentality' which claims 'they're all doped!'. And it does ignore the 'migration' by doping Athletes, into medical substances that have yet to be prohibited.


It is in the best interests of Sport: as a joy, as a business, a spectacle or a career, that this progress is acknowledged as a fact.


WADA should not mask its successes under statistics that seem to imply promotion of the inverse.




To be continued... "And..... action!"

..........@......... WADAWATCH
one hundred percent pure

copyright 2009 Ww


Friday, 29 February 2008

WADA LEAP YEAR 2008:

Fahey's first Tour, and Beijing


Is the best thing that's happening to WADA this year, the worst that possibly could happen to it? WADAwatch is not, repeat NOT, referring to WADA's newer, gentler president, nor anyone else.



This question is not meant to be confusing, nor will it remain so; WADA is banking on a newly formulated tool to combat the flux of doping:

the Athlete's Passport


By no means a 'government-authorized travel document', the “AP” was introduced to the sporting press at WADA's Press Symposium in Lausanne, Switzerland, on Wednesday the 27th February. In an all–day session hosted by WADA's president John Fahey, director general David Howman, and medical director, Dr Alain Garnier, participants were immersed in: the transition from Pound to Fahey, the role of Europe (which has pride enough in its sustenance of WADA, contributing 47.5 per cent of the operating budget) in WADA's governance, and the technical aspects (WADA PASSPORT for dummies?) of this Brave NEW Tool in the WADA toolbox.


Introduced as a 'pilot project', the Athletic Passport creates a longitudinal, auto-generated 'blue print' or record of each separate participant, being the 700 to 900 cyclists atop the UCI rankings. This concept 'in the pipeline' was elaborated, after the ashes cooled following the 'crisis' at last year's Tour de France, by the French Ministry of Health, Youth and Sport, ASO, the UCI and other interested Signatories of WADA. A meeting hosted by the French Ministry in October, 2007, attracted those participants, some of (whom WADAwatch is sure) were in no mood to accommodate their collaborators across the table.



There's only one small drawback: two of the participating organizations, vital to the success of this Longitudinal pursuit, should be straightjacketed and removed from civilization.



The UCI, which regulates the cycling world, and ASO, which is the French, privately-held company owning the Tour de France, amongst many other sporting events in the cycling world, etc., are doing their level best to out-piss the other in a war AGAINST CYCLING AS A SPORT, not at all indicative of success in cycling's the search for CREDIBILITY, new sponsorships, new talent, new glories...


Slides herein are from WADAwatch photos, however WADA did mention that their power Point presentations would be online shortly... visit this link, for the full set of presentations.

Sidebar: the 2009 WADA CODE is now online, it goes into effect in ten months:
1 January 2009.

(NB: it's not yet on the CODE page from the drop-down menu, follow links from the home page text to find it)


Thus IF the Honourable John Fahey can pass from Leap DAY (today!) to New Year, without the Tour de France and UCI throwing a stick in the spokes of this new and hopefully more effective monitoring system (which could go across to other sports if overwhelmingly validated), it remains to be seen if their Athlete's Passport will provide the right parameters.

The Athlete's Passport is not
a travel document!

(remember to can click on these photos, it opens
into a separate screen in 'full sized' mode)


Given all the interest that 'doping' has generated, and maybe in spite of the dearth of scientifically accurate, and truly well–written articles, the press that attended were quick to tie certain angles together.

WADAwatch had published, the preceding Friday, an article titled 'Five Easy Questions for John Fahey', and this article seeks to provide the appropriate responses, either directly from our questions, directly from the multiple presentations, or by gleaning appropriate comments from the responses directed to the journalists in the audience. The five questions (summarized) covered:

  1. WADA laboratory standardization vis–à–vis anecdotal press information to the contrary (occasionally, or specifically to certain labs);

  2. Further or future amendment possibilities to the WADA CODE, subsequent to this last World Conference in Madrid;

  3. The likelihood that Article 10.6 requires 'judicial interpretation' to see what it actually means, as an extra 'legal burden' to the first litigated Athletes whose legal defense must 'carry the water' for WADA's repeated opportunity, and now lost chance, to actually offer a 'legal definition' of what is 'Aggravating Circumstances';

  4. Why France is not in violation of WADA CODE Article 15.4, on Mutual Recognition, for its secondary litigation against Floyd Landis, during and after the USADA process was initiated and decided (although still pending appeal);

  5. The need, somewhere between WADA, its Signatories, and the International Olympic Committee, to draft a clear set of rules for Athletes, outlining their risks as members of teams, in the case where (Marion Jones) one participant may be found to be doped, yet the others are under no legal suspicion or suspension for that pertinent participation.


WADAwatch requests your indulgence; if errors are found we will certainly provide an updated article noting any corrections.

Laboratory standardization


Unfortunately, this issue was not directly discussed.

However, the 'undercurrent' provided by discussions of the panoply of measures being taken in combatting doping, appear to WADAwatch to be somewhat an admission that the science of medicine favors the cheating side.


The adage of our times is 'Law follows science' is never clearer than in this field, as it is easier to 'guinea pig' the Athletes who are seeking advantage, and harder for the scientists that must, of course, take time to cautiously determine proper testing methodologies, standardize the tests and publish, and then begin busting the guilty parties.

Marion Jones' history of successful evasion, throughout her career, of some 180–plus tests, is as good an example (or as sad...) of the need to augment capacities to measure biomarkers (blood or urine components), and has led to the abovementioned Athlete's Passport.


Further CODE revisions


WADAwatch asked David Howman, WADA's Director General, about the capacity of this organization to re-open CODE drafting, if and when it felt necessary, whether through feedback or 'judicial interpretation'; would it take another four years, until another presumed 'World Conference' had been called?

NB: The First World Conference on Doping in Sport was in 1999, in Lausanne, Switzerland (home of the IOC); the Second Conference was held in Copenhagen, Denmark, and the Third Conference was last November in Madrid, Spain.


Howman smiled and replied to the effect that, 'it appeared to be a trend, didn't it?', but that there really wasn't a formal requirement for a WCDS every four years. He continued by stressing that he wanted the CODE, as now modified and accepted, to be implemented to see where it had weaknesses, or success.


10.6 Aggravated Circumstances



In a separate follow-up to some other press questions, WADAwatch asked Howman again, if the lack of the redrafted CODE, with this entirely new article, didn't prejudice against any Athlete whose first litigation would help WADA achieve the definition they've chosen (in three redrafts) not to include, because: a- it poses an unfair financial burden on that first litigant to argue to CAS (Since it would be impossible to use a National ADO Decision as precedent-setting) what WADA's Article 10.6 DOES mean legally, and b- that CAS opinion could fall AGAINST WADA; did they relish incurring that risk?

Howman, who's far higher in his legal career (far more diplomas, than 'we WADAwatchers', definitely) emphasized, and rightly so, that WADA wasn't necessarily 'out to win' EVERY litigation; he stated that 'seeing justice prevail' was more important than whether WADA won or not.

WADAwatch takes heart in hearing those words, but of course it's a phrase that must be put to the test: ample cases in the past seemed to tend towards 'grasping at judicial straws', by seeking appeals from Federation decisions where, for one example, a national Federation was not a Signatory of WADA.

Future coverage of WADA's litigation excursions will remain a strong facet of WADAwatch.


15.4 Mutual Recognition



It's not embarrassing to admit a bit of nervousness, when asking these highly professional WADA officials about what appears to be, and which WADAwatch has described as, an 'outlaw decision' from the French AFLD, the Agence française pour le lutte contre le dopage.


In a rare gesture of discretion, WADAwatch won't reveal who muttered a clearly audible 'Oh, Jesus!' into his microphone.

David Howman did respond, afterwards, to our question concerning Floyd Landis' hearings and decisions in the USA. That judicial procedure was undertaken under the proper guise of WADA, UCI and the applicable US regulations from USA Cycling and USADA, with evidence from the French laboratory formally named the LNDD.

David's response was brief and (IWwHO) deflecting this inquiry off the scene, indicating that it was 'done under their previous law', and thus 'not in conflict with the US process'.

WADAwatch has sought from WADA, earlier today, a precision to that response.

It shouldn't be allowed, under Article 15.4, that a cyclist who's been suspended in the USA, faces another Signatory's disciplinary process, period 'point finale'. See 'BAFFLED by AFLD: an afterword' or 'Paths of GLORI (-ous French Failure)'

France could run twenty different Floyd Landis proceedings, under any law it chose, during or after USADA had its winning case decided (while the dissent from Chris Campbell distinguished itself in the Sports Law legal Hall of Fame by branding, in his very first sentence, the French lab (and thus its evidence) as being 'untrustworthy'): not one instance can be claimed that this would be (in our opinion) anything BUT an 'outlaw' process.

Stay tuned...

Retrospective Rulemaking for
Team mates of 'convicted dopers'


WADAwatchers, sometimes there's not enough day in a day, to get answers to every question. Some, like discussing what to do with the team mates of Marion Jones, now that she's confessed. We're the first to admit that this question may be better off being addressed to the International Olympic Committee.


One aspect pertinent, and for which most people would be grateful to learn, is that WADA reminded our audience that it has always had, since publishing the first CODE in 2003, a definition of Teams to be:

“a sport in which the substitution of players is permitted during a Competition.


Thus relay teams, cycling teams, crew teams, freestyle water ballet teams, are NOT TEAMS. (We're not sure if we know or if WADA knows precisely what those multi-person, event-participants are going to be defined, but it could be another case of 'judicial interpretation'...

+ + + + + + + + +


This week is drawing to a close, and there is much more to come from this interesting Symposium. Come back Tuesday and see what more came from Lausanne...


Where will WADA be, On LEAP DAY 2012?

............@............WADAwatch

© 2008 ZENmud productions


Add to Technorati Favorites